It seems to me there is a need for a browser extension framework/polyfill that allows you to write code once, deploy to any browser. Would that even be possible?
It's a great way to integrate seamlessly with a third-party site like Gmail.
It in turn solves the "other site" problem, i.e., your customers don't want to go to yet another website.
The Chrome Web Store is a wonderful source of traffic.
All your friends are doing it.
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i find the readme scary. it encourages closing the web.
I agree in principal -- I'm not advocating that the whole internet be centralized to a few major websites. Having said that, integrating with a site like Gmail can be a good way for a small fish to get some traction.
If you abstract away the browser-specific API, it's not too hard to write a cross-browser extension. Here's one that runs on both Chrome and Safari:
http://code.google.com/p/marking-menu-js/source/browse/#svn%...
Notice how it implements the important bits of Chrome's extension API in terms of Safari's:
http://code.google.com/p/marking-menu-js/source/browse/trunk...
That allows you to easily port Chrome extensions over.